Good mutations available in all sizes

نویسندگان

چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

All in good time

Why is issue-by-issue bargaining a common phenomenon, even though it disallows the beneficial trade-offs across issues that are possible when negotiating a global solution? We show that under asymmetric information, issue-by-issue bargaining has two attractive features. First, it avoids bundling a good deal on one issue with a bad deal on another issue, when the lack of gains to agreement on th...

متن کامل

Algorithms for Learning Good Step Sizes

Many common algorithms in machine learning, from logistic regression to neural networks and beyond, rely on hyperparameters to function well. In gradient descent, too large a step size can cause the iteration to blow up and not terminate; too small a step size and the iteration doesn’t converge fast enough. Tuning these parameters can be very difficult: the manual for the popular linear and int...

متن کامل

Sample Sizes for All Patients With Initial

and power=80%, 1605 patients would be required in each group. If power=90%, the number of patients required in each group would be 2135. Table 1 provides sample size estimates for varying effect sizes (rounded to the nearest 5%) and powers of 80% or 90% with a=.05 for both the observed data (approximately 50% of patients demonstrating major improvement) and the upper and lower bounds of the 95%...

متن کامل

GenomePro - Processing Genomic Files Of All Sizes

We have developed a computational framework called GenomePro that allows us to process genomic files, of all sizes, from multiple formats such as NGS, fasta, and GBK, extracting DNA, RNA and Protein sub-sequences of any length, limited by the storage size or operating system. GenomePro creates a data structure that contains subsequences of any size used to develop new tools that allow us to fur...

متن کامل

WT1 mutations in T-ALL.

The molecular mechanisms involved in disease progression and relapse in T-cell acute lymphoblastic leukemia (T-ALL) are poorly understood. We used single nucleotide polymorphism array analysis to analyze paired diagnostic and relapsed T-ALL samples to identify recurrent genetic alterations in T-ALL. This analysis showed that diagnosis and relapsed cases have common genetic alterations, but also...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Nature Reviews Microbiology

سال: 2009

ISSN: 1740-1526,1740-1534

DOI: 10.1038/nrmicro2134